Title : HIV genes have been cut from live animals Using CRISPR
link : HIV genes have been cut from live animals Using CRISPR
HIV genes have been cut from live animals Using CRISPR
initially, scientists led by Kamel Khalili, director of the NeuroAIDS Integral Center at Temple University, published in the journal gene therapy having first HIV genes successfully removed from the genomes of mice and rats infected with the virus.
While rodents are not infected with HIV in the same way that humans do, Khalili and his team designed the animals to incorporate specific genes of HIV in almost every cell in your body, from the brain, heart, liver, lung kidney and spleen their blood cells. Then they created a pair of molecular scissors using a technique called gene edition CRISPR to cut the viral genes. CRISPR power lies in the fact that it is accurate enough to find and cut only the viral genes, leaving intact animal DNA itself.
In previous studies, Khalili cut them uses CRISPR HIV from cells taken from HIV positive people and grown in a laboratory dish. But show it works in a living animal is a big step forward for the development of the technique as a possible treatment, cure or even HIV-AIDS.
The study, Khalili studied the ability of CRISPR to eliminate HIV from the two mice and rat models, and found that, overall, was successful in cutting the virus in more than 50% cells of each type. Surprisingly, he did it with two simple injections of molecular scissors CRISPR into a tail vein of animals. "It's very simple," he says. "If this technology gets into the clinic to treat human patients, it will not be very complicated. You do not have to take the patient to the clinic and do a bone marrow transplant or all kinds of complicated technology. It is basically can apply this to any environment. "
that's important is that this technique finally becomes a way to treat people infected with HIV, since most of them live in countries developed where health facilities are not always available.
Khalili says this is only one step, albeit an important one, towards that goal. It is currently conducting further studies to determine what dose and how often CRISPR consider necessary, and monitoring of treatment side effects as well. Because the molecule CRISPR addresses the HIV genes it is unlikely to have adverse effects on human DNA, but it remains an open question that doctors and regulators such as the Food and Drug Administration need to know before allowing the strategy to be tested in human patients.
However, if possible HIV eliminated from people who are infected, that could open the way to cure people of disease. While HIV drugs are highly effective in reducing viral levels still they can not ferret to the last hiding virus, latent in some cells. Those hidden HIV reservoirs are the most dangerous - can reactivate and cause disease years after the initial infection. But if CRISPR can remove them, then that would essentially cure people of their infection. "The first step is to inactivate the virus permanently incorporated into the cells," says Khalili. "If we can do that, and get to that level, then we may be able to functionally cure individuals or have a sterilizing cure."
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