Title : Chondroitin benefits for osteoarthritis and joint pain
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Chondroitin benefits for osteoarthritis and joint pain
Chondroitin is one of the most sought after joint support supplements available on the market today because of the way it helps rebuild cartilage naturally and increases tissue recovery after injury or exercise. Commonly available in formulations containing similar and complementary supplements like glucosamine and HSH , which is taken by many people with joint pain . Osteoarthritis , and other signs of "wear and tear" due to aging
These substances are often used together because they have similar mechanisms to reduce inflammation and pain - also they're considered very safe and low risk of side effects. Although not all studies have shown that chondroitin is able to help those who suffer joint pain, many studies show that support for its efficacy and safety.
is an important structural component of cartilage and one of the key substances which enables joints to withstand pressure. The Natural Medicines Comprehensive Database classified Chondroitin as "possibly effective" for osteoarthritis (and glucosamine as "probably effective"), and many other authorities are behind their use fight against pain in joints Natural form instead of prescriptions. ( 1 2 )
What is Chondroitin?
Chondroitin is a natural substance in the human body and a major component of cartilage, which helps build connective tissue throughout the body, including those that form the joints and the gastrointestinal tract (GI ). Because it works by retaining water, which helps put lubrication and flexibility of tissues and joints.
When found in supplement form, or may be naturally occurring cartilage of animals (including cows, pigs or sharks) or artificial. Drinking bone broth is probably the best way to get both glucosamine and chondroitin at home.
The form of chondroitin performed in the laboratory is called chondroitin sulfate, which is a combination of chondroitin salts and minerals that help improve absorption. ( 3 ) supplements containing chondroitin can go by many different names depending on the specific formulation of the product: glucosamine, chondroitin glucosamine and chondroitin sulfate are all names that may arise, for example. Although the terminology may seem confusing, various forms available can mostly all be used in the same way.
Chondroitin Benefits and uses
1. helps treat osteoarthritis joint pain
estimates indicate that more than 27 million adults in the US living with osteoarthritis, which is the most common type of arthritis degenerative joint disease characterized by the breakdown of cartilage and increased joint pain. Chondroitin sulfate is commonly used to treat pain associated with osteoarthritis, especially forms affect sensitive parts of the body, such as knees and hands.
In general, studies have shown that the use of chondroitin tends to cause modest improvements in joint pain over the course of several months, although some people experience even more benefits and faster - especially when combine various supplements together and make other changes like eating a arthritis diet to treat the symptoms. According to the Arthritis Foundation, on average, study participants usually experience an improvement of 10 percent in the painful symptoms when chondroitin is used compared to placebo. The best results are usually achieved after using a product containing for three months or more. ( 4 )
Recently, the University Medical School of Utah conducted the largest clinical study on the effects of chondroitin and glucosamine, called "Glucosamine / chondroitin Arthritis Intervention Trial (gAIT). "according to the reports published by the National Center for complementary and Alternative Medicine, the march is the first large-scale, multicenter clinical trial in the US to test the effects of dietary supplements glucosamine hydrochloride (glucosamine) and sodium chondroitin sulfate (chondroitin sulfate) for the treatment of osteoarthritis of the knee. ( 5 )
- The GAIT study compared the effects of glucosamine and chondroitin sulfate (used separately and in combination) for the purpose of placebo and medication prescription.
- 16 rheumatology research centers in the US and more than 1,500 patients participated in the study, which lasted six months.
- patients received one of five treatments over the course of six months, including the use of glucosamine and chondroitin celecoxib (a drug popular prescription used to treat osteoarthritis pain) or placebo. A positive response to any treatment was defined as a 20 percent or greater reduction in pain after six months compared with baseline.
- The results of the GAIT study showed that participants with moderate to severe pain, glucosamine combined with chondroitin sulfate provided relief statistically significant pain compared to placebo - about 79 percent had a reduction 20 percent or more in the actually worked pain versus about 54 percent for the placebo group
- Chondr0itin and glucosamine for more. people who made prescription -. 70 percent of the participants in the celecoxib group experienced pain relief compared to placebo
- However, participants in the mild sulfate subset pain, glucosamine and chondroitin seemed to do less to reduce their pain. These participants, on average, experienced no statistically significant relief as those with more severe pain did pain.
The results of another double-blind, randomized, placebo-controlled study, which appeared in arthritis and Rheumatism tested the effects of chondroitin taken by 162 symptomatic patients with osteoarthritis hand. The results showed that patients experiencing chronic pain of hands and took 800 milligrams of chondroitin sulfate (CS) per day experienced in relieving modest average pain sulfate reducing morning stiffness and improved overall functionality of three to six month regular use.
researchers also found that most patients experienced no adverse side effects due to chondroitin, which often can not be said of other drugs to relieve pain that can cause adverse effects such as stomach ulcers , dependence, digestive problems, problems with blood pressure and more. The conclusion of the researchers was that "CS improves hand pain and function in patients with symptomatic osteoarthritis of the hand and shows a good safety profile." ( 6 )
2 . help with injuries and exercise recovery
Even for people without osteoarthritis, evidence suggests that chondroitin is used with glucosamine helps preserve valuable cartilage, decreases pain, increases improving physical function and self-care activities. ( 7 ) can reduce joint stress after exercise or injury, helping the body to synthesize new cartilage, keeping joints flexible and control of natural inflammatory responses of the body.
3. Improves wound healing and skin Health
chondroitin and glucosamine are also used together to help heal wounds, skin-related defects , skin inflammation and even in veterinary medicine. Chondroitin can help the body produce collagen , which is essential for skin health, healing and combating the effects of aging on the skin.
Treatments performed using glucosamine chondroitin and are often used for wound dressing, even for serious injuries also applied on scrapes, burns and injuries keep moist wounds and promote faster recovery. ( 8 ) Some studies have even found that in patients with burns requiring skin grafting, use of chondroitin gel treatment can speed healing time and help control inflammation significantly.
How Chondroitin works
Chondroitin is a component primary human extracellular matrix, and linking sugar and protein molecules and serves an important role in maintaining the structural integrity of the tissue. Its main benefit and mechanism of action is stimulating the regeneration of cartilage, which is the connective tissue that cushions the ends of bones in joints.
Within chondroitin sulfate groups are forming a barrier that can withstand tight compression, shock and even electrostatic charges that damage tissues. Chondroitin is technically a form of a complex carbohydrate, giving bumps and capabilities and therefore is crucial to allow movement of the joint / bone frictionless water absorption. This is why the loss of cartilage chondroitin is a major cause of osteoarthritis degenerating joints.
is also important for tissue formation in other parts of the body including the skin, GI tract and brain. As it regards the brain extracellular matrix, which helps stabilize normal brain synapses and protects the brain against injury. After trauma to the brain, chondroitin levels increase rapidly to help regenerate new tissue in order to replace the damaged nerve endings.
Chondroitin compared to NSAIDs
Today, chondroitin, especially when taken together with glucosamine, is a popularly prescribed anti-inflammatory drugs alternative (NSAIDs), which are prescribed or over-the-counter pain medications used to treat chronic inflammation and pain.
NSAIDs are used daily, or at least very frequently by millions of patients who have to do with chronic pain due to various health conditions. Many of the side effects experienced as a result of the use of NSAIDs, such as gastrointestinal disturbances, including low heartburn , and are not able to take long-term NSAID. Although very few studies conducted over a long period of time have directly compared the efficacy of Chondroitin with NSAIDs, the two seem to function similarly to way reduction of bone pain or joint and improved functionality, although that chondroitin may take a little longer to work than NSAIDs.
NSAIDs tend to reduce pain more quickly (usually within several weeks), but then the effects usually disappear. At this point, the benefits of chondroitin and glucosamine actually are becoming more evident as it takes them some time to start reducing inflammation and stimulate cartilage production. Chondroitin is the most studied in relation to the treatment of the symptoms of osteoarthritis, but research also shows that could also help treat other problems such as digestive disorders and signs of aging on the skin as well.
Chondroitin is used with glucosamine
What is Glucosamine, and how it differs from chondroitin?
Glucosamine is also a natural anti-inflammatory compound found in human cartilage and connective tissue. Technically, glucosamine is an amino sugar the body produces and distributes where the tissue is found. It is naturally abundant in fluids surrounding the joints and in supplement form are sold for the same purposes as chondroitin sulfate.
Studies have found that glucosamine has cartilage regeneration effects and increases the strength and flexibility of joints. Glucosamine sulfate is the most frequently used today to treat joint pain and osteoarthritis, which is a combination of glucosamine salts and minerals that the body can easily absorb.
Glucosamine Chondroitin used to help lower symptoms associated with loss of collagen and cartilage, found in tendons, joints, ligaments, skin and digestive tract. These conditions may include tendinitis , bursitis and so on. In healthy people, when the cartilage is damaged due to overuse, injury or inflammation, the new cartilage is normally produced to take their place. Unfortunately, as we age our ability to regenerate lost cartilage and repair damaged connective tissue becomes less efficient.
In humans and animals, glucosamine and chondroitin stimulate the production of new cartilage and can also help reduce inflammation in the process. Today, these supplements are available in tablet, capsule, powder or liquid form and can be consumed safely with most medications or other dietary supplements. To date, most research has been done in regard to the benefits of glucosamine, although the two are often combined to obtain better results. When together benefits are taken they include:
- reduce joint pain
- enhanced functionality of patients with arthritis
- improving skin health
- better digestive function
- bone healing
- healing faster wounds
chondroitin Recommended dosage
at this time, there is no recommended daily intake chondroitin or glucosamine. The GAIT study uses these supplements in the following doses:
- glucosamine alone: 1,500 milligrams a day, taken as 500 milligrams three times a day
- sulfate Chondroitin: 1,200 milligrams per day, taken as 400 mg three times a day. Other studies have used doses of about 800 milligrams per day and yet some results are
- glucosamine, chondroitin sulfate combined: same doses - 1,500 milligrams per day and 800-1200 mg
- All GAIT study participants also seek an analgesic counter ( acetaminophen ), regardless of treatment group were. analgesics found over the counter to make sure the use of these two supplements, so that participants were allowed to take up to 4,000 milligrams (tablets of 500 milligrams) a day to control pain except for 24 hours before pain
glucosamine and chondroitin side effects and precautions [19459008evaluated]
even though these supplements are unlikely to cause side effects and can help control pain naturally, that does not necessarily work for everyone and therefore should not take instead of your other medications unless you have consulted with your doctor. It seems that these supplements are most useful when used long term and in combination with other lifestyle factors -. As an anti-inflammatory diet, exercise, stretching and stress reduction
Currently, the American College of Rheumatology does not recommend either for initial treatment of osteoarthritis but they are behind their use as safe and alternative methods to control pain after inflammation associated with osteoarthritis has begun to decline. ( 9 ) the most effective, a brand of high quality Chondroitin combines several substances as a whole should take at least three months and is used in appropriate doses.
The good news is that these supplements are safe to take even if you've had problems with other analgesics. Studies show that the use of these supplements regularly for up to three years presents little risk of side effects. The amount of benefit you get from taking them ultimately depends on your starting level of inflammation, the amount of joint deterioration that has experienced, medical history and other lifestyles.
The Arthritis Foundation says these probable supplements is not effective for all patients, but "for those who take these supplements and have seen improvements with them should not stop taking them. They are safe for use long term. "
key Findings About chondroitin
- is a natural substance that helps build cartilage.
- chondroitin and glucosamine are both considered to be very safe and effective ways to reduce joint pain.
- can be used in place of NSAIDs in patients requiring long-term treatment and help control pain, including. those associated with osteoarthritis
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