Title : Scientsts seek genetic clues about why asthma is more deadly in black
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Scientsts seek genetic clues about why asthma is more deadly in black
Zunika Crenshaw helps her 3-year-old daughter Jhase Crenshaw Bass with an asthma inhaler.
Lesley McClurg / KQED
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Lesley McClurg / KQED
Zunika Crenshaw helps her 3-year-old daughter Jhase Crenshaw Bass with an asthma inhaler.
Lesley McClurg / KQED
Zunika Crenshaw shrinks as a swing plaguing their children in circles a little too fast. It's a sunny afternoon in the park, in Pleasanton, California. As your children play, a close eye on her breathing is maintained.
She says that asthma is in their genes.
"You have a family, a person who has four children, and they all have, including me," she says. "And then my mother has it, and two children of my sister."
A 3-year-old Jhase, runs to her, wheezing. Crenshaw grab an inhaler, and breathe deeply of her daughter.
"Perfect!" Jhase says. She leans her head against her mother's chest, then runs back to his brothers.
Crenshaw drops the inhaler in a lot of drugs in her purse. She points to several bottles of pills.
"Zyrtec, and this is ClariSpray. And there albuterol and Dulera".
There are more drugs in the country.
Asthma is the leading chronic disease of children, but hitting some more difficult populations than others.
According to Centers for Disease Control and Prevention Disease, black children are twice as likely to have asthma than white children. And black children are 10 times more likely than whites to die from complications of asthma children.
A team of scientists from the University of California at San Francisco, is on a mission to understand why. Researchers are delving into the genetic clues that may have been overlooked so far.
geneticist Marquitta White has just published a study finding that most scientists of the genetic information for the asthma patient does not apply to African Americans.
"Most genetic studies, not only in asthma, but in most diseases are performed in Caucasian-or populations of European descent," White explains. "Longer studies are not really very many minority populations, which means that most patients are not getting the best care because it is not known very well what is the etiology of the disease is in its population in particular . "
The drugs also work differently in different populations, according to Esteban Buchard, a pulmonologist at UCSF. As an example, points to the fine print on the instructions of a medicament for the common Advair asthma is called.
"It specifically says that if you're African American and you take this, you have a risk of death eight times," he says.
Zunika Crenshaw packs her bag full of medications for asthma and allergies when their children reach the park near his home in Pleasanton, California.
Lesley McClurg / KQED
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Lesley McClurg / KQED
Zunika Crenshaw pack your bag full of medications for asthma and allergies when their children reach the park near his home in Pleasanton, California.
Lesley McClurg / KQED
The UCSF team is analyzing the genes of black children, Mexican-American, and Puerto Rico to better understand the drug responses in each population.
"One of our hypotheses is that what underlies this great mortality in African-American children is the fact that the most commonly prescribed medication for asthma is albuterol," says White. "The problem is that not everyone responds to albuterol in the same way. And in fact, African-American children in Puerto Rico and have the worst response to drugs. So you're looking at two populations with the response to worse drugs increased mortality. We feel those things might be related. "
matter refine drugs
Good treatment is key to preventing the types of severe asthma attacks that keep children home sick.
The Crenshaw children miss fewer school days since they started visiting Breathmobile , a long caravan converted into an asthma clinic. The clinic is run by a nonprofit organization called the Prescott-Joseph Center . It travels throughout the East Bay that offers free treatment to low-income families.
Inside, a medical assistant tests the lungs of a girl 5 years old who has made playing with her tight braids. The doctor pauses several times so the girl can blow your nose.
A test lung in the Breathmobile found that lung function of 5-year-old Brooklyn Turner is compromised by their asthma.
Lesley McClurg / KQED
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Lesley McClurg / KQED
a test lung in the Breathmobile found that lung function of 5-year-old Brooklyn Turner is compromised by their asthma.
Lesley McClurg / KQED
Pat Granberg, a pediatrician, mother of the girl on their living conditions wonders, your neighborhood and your financial situation to determine probable asthma triggers. The disease can be caused by a number of factors, including obesity, air pollution, access to health, fungus, mold, pets, perfumes and smoking. But Granberg starts an evaluation asking if asthma runs in the family, because usually there is a genetic link.
One size does not fit all
"On average, 60 percent what will determine whether you have asthma will be due to genetic factors, "says White. It says depending on the population, that number could range from 35 to 90 percent.
"I think what we should be fighting for attention is the same for everyone," says White, "and in order to do that you have to know what the disease is doing around the world. This is the first step ".
Buchard think a lot of health disparities could be explained if more minorities were included in genetic research. To illustrate this point, you look back to when researchers studied heart disease only in men.
"Women today differently than men do for heart attacks," says Buchard. "So a whole generation of physicians diagnose misclassifying and women simply because women were not involved in the original clinical trials."
In 1993, Congress passed legislation requires doctors publicly funded studies include more minorities. However, a 2015 review study lung diseases found only 5 percent of publicly funded research included patients of color.
This history originally appeared on KQED's blog Future you .
The post Scientsts seek genetic clues about why asthma is more deadly in black appeared first on https://www.flynewsonline.com/2016/06/07/scientsts-seek-genetic-clues-to-why-asthma-is-deadlier-in-blacks/
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