The importance of ESR

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The importance of ESR

blog5 ESR is a test used to detect inflammation in the body. Inflammation may be due to an underlying infection, such as cold or stomach infection, autoimmune disease such as arthritis, or even cancers. So although the VSG increases when there is inflammation, the test is not specific, ie it does not clearly indicate what is the cause of inflammation.

However, once the cause is determined, the gradual decrease in ESR is indicative of improvement in the state. ESR and helps control disease activity and the body's response to therapy.

What are the erythrocytes? What is settling?

Blood contains cells floating in the liquid. Thus, once the blood is collected in a tube (thin tube height), solid components of blood begin to settle at the bottom. red blood cells (erythrocytes) tend to settle at the bottom of the tube and the speed at which so is recorded as the erythrocyte sedimentation rate.

Now, in case of inflammation, the red blood cells tend to group and these groups are denser than the individual cells, so that sedimented faster. So the distance of the red blood cells to fall (in mm) in the test tube in given time (1 hour) increases as indicated by an increase in ESR. High ESR and means greater inflammatory response of the immune system.

Reference ranges for ESR in healthy adults

adults upper limit of the reference range (mm / h)
Age <50 years
Men 0 to 15
Women 0 to 20
age> 50 years old
Men 0 to 20
Women 0 to 30

ESR = erythrocyte sedimentation rate.

Information Bottiger LE, Svedberg CA. erythrocyte sedimentation rate normal and age. Br Med J 1967; 2:. 85-7

ESR can be subnormal in the following circumstances:

  • A disease or condition that increases the production of red blood cells
  • a disease or condition that increases the production of white blood cells
  • sickle cell anemia (abnormal red blood cells)

ESR can be higher than normal if there is an underlying illness or problem that is causing inflammation, such as:

  • Arthritis
  • autoimmune disease (a disease that causes your body to attack its own tissues such as lupus)
  • Infection
  • Cancer

the VSG is also higher during pregnancy or if you have kidney or thyroid.

The family doctor takes into account all factors, such as medical history, clinical symptoms and other blood parameters before making a clear diagnosis.

So every time you get a complete blood count finished, be sure to look ESR levels.

References:

http://www.mayoclinic.org/tests-procedures/sed-rate/home/ovc-20207006

http://www.summitmedicalgroup.com/library/adult_health/aha_esr_test/

https://labtestsonline.org/understanding/analytes/esr/tab/test/

http://www.aafp.org/afp/1999/1001/p1443.html





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