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popular pain drug linked to birth defects

pregabalin, sold under the name Lyrica, is approved in the US to treat nerve pain, including fibromyalgia and pain caused by shingles and diabetes, as well as seizures. Some doctors are also prescribing the drug off-label for generalized anxiety disorder. But the latest study shows that it can contribute to birth defects as well.

A report published in the journal neurology , researchers Service Switzerland Information teratogen, a facility that collects reports of possible harmful effects of drugs, found that women who took Lyrica pregabalin or during pregnancy had a higher risk of having babies with birth defects. The risk of birth defects was three times higher if pregnant mothers took the drug during the first trimester.

Combined with animal studies also showed a higher rate of neural tube defects and skeletal among those exposed to pregabalin, the findings raise concerns about the risk for pregnant women.

The label to indicate that pregabalin is not recommended for women who are expecting, or hoping to become pregnant. But as the study's lead author, Dr. Thierry Buclin points out, many pregnancies are unplanned, meaning that women taking the drug could be unknowingly exposing their fetuses in utero to the drug. In fact, in the study, 77% of women were drug before they learned they were expecting.

"We checked in and checked all the results," says Buclin. "We were a little surprised by the positive result of the higher birth defects. Definitely relative".

Buclin says it is the first study to find the link, so more research is needed to confirm the results, since women who took pregabalin were more likely to be taking other medications, and also more likely smoking. But the connection between birth defects and drug remained strong even after the scientists adjusted to these potential effects.

Even with the tripling of risk, however, the chances of birth defects to begin with is very small, so the drug may contribute to negligible absolute increase for any particular woman.

Still, Buclin says, "must be increased caution in prescriptions for women of childbearing age." Few studies include pregnant women for fear of harming the developing fetus, but the truth is that many pregnant women are dependent and need medication. Having a better understanding of what drugs would be safe for them and their babies, and drugs that are not, is more useful than simply advise avoiding drugs altogether.

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